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  1. Inhibition of this enzyme may interfere with the biosynthesis of nucleic acids and proteins. In clinical trials in patients with bipolar disorder, 2 patients experienced seizures shortly after abrupt withdrawal of lamictal; however, there were confounding factors that may have contributed to Lamotrigine vs lamictal the occurrence of seizures in these patients with bipolar disorder. E Slight decrease, not expected to be clinically meaningful.